They were randomized to receive feverfew 6.25 mg 3 times daily or placebo for 16 weeks. Feverfew also has been planted around houses to purify the air because of its strong, lasting odor; a tincture of its blossoms is used as an insect repellant and balm for bites.2 It has been used as an antidote for opium overdose.1, The chemistry of feverfew is well defined. They resemble those of chamomile (Matricaria chamomilla), for which they are sometimes confused, and have a single layer of white outer-ray florets.5, 9, 10, 11. Read more! Parthenolide noncompetitively antagonized the contractions elicited by the serotonergic action of fenfluramine and dextroamphetamine on the fundal tissue. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. An adult dosage for the prevention of migraine headaches should be equivalent to 0.2 to 0.6 mg/day of parentholide; however, this compound has not been confirmed as a major active principle for migraine.83, 87 Patients may prefer to take feverfew with food due to its bitter taste. For thousands of years, feverfew has been used to prevent pain throughout the body, not just the pain of headaches and migraines. However, among the main uses of this plant are medicinal ones thanks to its properties. Migraine frequency declined from 4.8 attacks to 2.9 attacks (−1.9 ± 0.2) in patients treated with feverfew compared with 3.5 attacks (−1.3 ± 0.2) with placebo at weeks 5 through 12. Feverfew can induce widespread inflammation of the oral mucosa and tongue, often with lip swelling and loss of taste. The stem of the plant is hairy in appearance and contains green leaves. Consider therapy modification.95, 96, 97, 98, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. Feverfew extracts are not only potent inhibitors of serotonin release from platelets but also of polymorphonuclear leukocyte granules, providing a possible connection between the claimed benefit of feverfew in migraines and arthritis.5, 12, 30, 36, 46, 47, 48, 49, Chloroform leaf extracts of feverfew inhibited the contraction and relaxation of rabbit aorta. GI effects, such as abdominal pain, nausea, vomiting, diarrhea, indigestion, and flatulence, may also occur. Health benefits of apple cider vinegar include its ability to regulate blood sugar levels, boost weight loss, improve skin & gut health, & lower cholesterol levels.Read more! Feverfew is an excellent remedy in treating Headache. Parthenolide also enhanced the production of nitric oxide and superoxide anion in all of the ALL cells.55 Thus, parthenolide may be a future treatment option for patients with leukemia to selectively destroy the leukemic stem cells while sparing normal stem cells. Feverfew uses also included addressing symptoms related to rheumatism, joint inflammation and the early stages of arthritis. Feverfew action does not appear to be limited to a single mechanism. In the mid-nineteenth century, feverfew was introduced in the United States. Additionally, an ethanolic extract of feverfew inhibited the growth of 2 human breast cancer lines, human glioblastoma cell lines, and 1 human cervical cancer cell line. Feverfew side effects. We source information from studies, clinical trial findings, and meta-analyses published in peer-reviewed journals. Parthenolide is found in the superficial leaf glands (0.2% to 0.5%), but not in the stems, and comprises up to 85% of the total sesquiterpene content.5, 12, 17, 18 Factors such as the geographical location of seed origin, stage of plant growth at harvest, plant parts used, and duration and condition of storage can all affect the parentholide content.7 A study revealed that degradation of parthenolide in a feverfew solution follows a first-order reaction. While some people grow feverfew as an ornamental flower, due to its aesthetically appealing flowers, this plant scientifically known as Tanacetum parthenium is far more commonly used in traditional medicine and modern herbal therapies. The powerful health benefits of dates include providing an energy boost, increasing iron in the body, and aiding digestion.Â. Herbalists traditionally espouse the benefits of feverfew medicinal uses as a treatment for headaches, stomachaches, fever, arthritis, psoriasis, menstrual problems and labor pain. Results from the meta-analysis reported insufficient evidence to conclude whether feverfew was superior to placebo in reducing the frequency and severity of migraine attacks, incidence and severity of nausea and vomiting, and global assessment of efficacy in patients with migraine headaches. Relief from a Migraine, Stress, and Anxiety. Do you want the best of science-backed health & nutrition information in your inbox? Feverfew is a women herb. ( 1 ) Feverfew’s pain-easing effect is said to come from a biochemical called parthenolides, which combat the widening of blood vessels that occurs in migraines. Upon patch testing, both women tested positive to various allergens including a sesquiterpene lactone mix and the moisturizer, leading to the conclusion that feverfew moisturizer was responsible for their dermatitis.50, 69, 100, 101 Other adverse effects have included nausea, vomiting, abdominal pain, diarrhea, indigestion, and flatulence.7, Because no studies of long-term toxicity have been performed on the plant, the safety of feverfew use has not been established. As a stimulant it is usefulas an emmenagogue. Feverfew has been linked to certain hormonal activity that induces hunger. Native to the Balkan Peninsula, feverfew is now found in Australia, Europe, China, Japan, and North Africa. Consider therapy modification.95, 96, 97, 98, Salicylates: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of salicylates. Parthenolide is the active ingredient that receives the most attention, but feverfew also contains a variety of oils and tannins that also have effects on human health. No studies of chronic toxicity have been performed on the plant. Benefits of ferverfew are well-known for their properties of treating migraines and headaches. Numerous feverfew products are commercially available ; most are standardized to parthenolide 0.7 in! Juice include bleaching the skin, detoxifying the body, not just the pain, morning,. A total of 5 randomized, placebo-controlled trial a useful healing plant powerful... Plant with powerful medicinal action found in Australia, Europe, China, Japan, if! For centuries groups self-medicated with feverfew use, mineral or other dietary supplement several years before enrolling in the of! 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